Tweats, D.J.: search on Z-Library

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1

TARGETS AND MECHANISMS OF CHEMICALLY INDUCED ANEUPLOIDY. PART 1 OF THE REPORT OF THE 2017 IWGT WORKGROUP ON ASSESSING THE RISK OF ANEUGENS FOR CARCINOGENESIS AND HEREDITARY DISEASES

Lynch, Anthony M., Eastmond, David, Elhajouji, Azeddine, Froetschl, Roland, Kirsch-Volders, Micheline, Marchetti, Francesco, Masumura, Kenichi, Pacchierotti, Francesca, Schuler, Maik, Tweats, David

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2019

Language:

english

File:

PDF, 415 KB

english, 2019

2

1-Aryl-4-nitro-1H-imidazoles, a new promising series for the treatment of human African trypanosomiasis

Bernadette Bourdin Trunz, Rafał Jędrysiak, David Tweats, Reto Brun, Marcel Kaiser, Jerzy Suwiński, Els Torreele

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 398 KB

english, 2011

3

Report of the IWGT working group on strategy/interpretation for regulatory in vivo tests: II. Identification of in vivo-only positive compounds in the bone marrow micronucleus test

D.J. Tweats, D. Blakey, R.H. Heflich, A. Jacobs, S.D. Jacobsen, T. Morita, T. Nohmi, M.R. O’Donovan, Y.F. Sasaki, T. Sofuni, R. Tice

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 321 KB

english, 2007

4

Mutagen formation after the addition of nitrite to normal human gastric juice

Gatehouse, David G., Tweats, David J.

Journal:

Year:

1982

Language:

english

File:

PDF, 181 KB

english, 1982

5

Genotoxicity studies of gastric acid inhibiting drugs

Burlinson, B, Morriss, S.H, Gatehouse, D.G, Tweats, D.J, Ekman, Lars, Bolcsfoldi, George, Macdonald, James, Nicols, Warren

Journal:

Year:

1990

Language:

english

File:

PDF, 324 KB

english, 1990

6

Comparative studies on the gastric acid inhibiting drugs (loxtidine, ranitidine, cimetidine and omeprazole) using the in vivo stomach UDS assay

B. Burlinson, S. Morriss, D. Gatehouse, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1991

Language:

english

File:

PDF, 85 KB

english, 1991

7

Report of the IWGT working group on strategies and interpretation of regulatory in vivo tests: I. Increases in micronucleated bone marrow cells in rodents that do not indicate genotoxic hazards

D.J. Tweats, D. Blakey, R.H. Heflich, A. Jacobs, S.D. Jacobsen, T. Morita, T. Nohmi, M.R. O’Donovan, Y.F. Sasaki, T. Sofuni, R. Tice

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 533 KB

english, 2007

8

Future approaches for genotoxicity testing of drugs and impurities

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 50 KB

english, 2010

9

Uptake of tritiated thymidine by cells of the rat gastric mucosa after exposure to loxtidine or omeprazole

Burlinson, B., Morriss, S., Gatehouse, D. G., Tweats, D. J., Jackson, M. R. M

Journal:

Year:

1991

Language:

english

File:

PDF, 1.57 MB

english, 1991

10

Monitoring the marine environment for mutagens

PARRY, J. M., TWEATS, D. J., AL-MOSSAWI, M. A. J.

Journal:

Year:

1976

File:

PDF, 350 KB

1976

11

Proposal to update and remove the carcinogenic classification assigned to iodomethane

Bowen, Damian, Rose, Patrick, Leconte, Florence, Tweats, David

Journal:

Toxicology Letters

Year:

2014

Language:

english

File:

PDF, 63 KB

english, 2014

12

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity

Tweats, David J., Johnson, George E., Scandale, Ivan, Whitwell, James, Evans, Dean B.

Journal:

Year:

2016

Language:

english

File:

PDF, 4.15 MB

english, 2016

13

Cell-based assays

Fielder, Robin J., Wood, G. M., Benford, Diane J., Robertson, W. R., Lambert, A., Tweats, D. J.

Journal:

Analytical Proceedings

Year:

1992

Language:

english

File:

PDF, 2.02 MB

english, 1992

14

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept®, Roche): overview

Anton Pozniak, Lutz Müller, Miklos Salgo, Judith K Jones, Peter Larson, David Tweats

Journal:

AIDS Research and Therapy

Year:

2009

Language:

english

File:

PDF, 675 KB

english, 2009

15

Retroviral transduction with SOX9 enhances re-expression of the chondrocyte phenotype in passaged osteoarthritic human articular chondrocytes

Simon R. Tew, Ying Li, Peraphan Pothacharoen, Lisa M. Tweats, Robert E. Hawkins, Timothy E. Hardingham

Journal:

Osteoarthritis and Cartilage

Year:

2005

Language:

english

File:

PDF, 594 KB

english, 2005

16

The Viracept-EMS case: Impact and outlook

Vernon E. Walker, Daniel A. Casciano, David J. Tweats

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 252 KB

english, 2009

17

Metaphase analysis of mouse spermatogonial cells following exposure to ranitidine

D.J. Parkes, S.A. Pascoe, D.G. Gatehouse, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1984

Language:

english

File:

PDF, 147 KB

english, 1984

18

An analysis of results from 305 compounds tested with the yeast RAD54-GFP genotoxicity assay (GreenScreen GC) including relative predictivity of regulatory tests and rodent carcinogenesis and performance with autofluorescent and coloured compounds

Knight, A. W., Billinton, N., Cahill, P. A., Scott, A., Harvey, J. S., Roberts, K. J., Tweats, D. J., Keenan, P. O., Walmsley, R. M.

Journal:

Year:

2007

Language:

english

File:

PDF, 119 KB

english, 2007

19

Book Reviews

Journal:

Year:

1985

Language:

english

File:

PDF, 25 KB

english, 1985

20

O XIX A.1 - O XIX A.1 ICH harmonisation of genotoxicity testing for pharmaceuticals; consequences for industry and regulatory bodies

Lutz Müller, David Tweats, Toshio Sofuni, Leonard Schechtman, Gregory Probst, Hiroyasu Shimada

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1997

Language:

english

File:

PDF, 97 KB

english, 1997

21

R Factor-mediated Resistance to Ultraviolet Light in Strains of Escherichia coli Deficient in Known Repair Functions

Tweats, D. J., Thompson, M. J., Pinney, R. J., Smith, J. T.

Journal:

Journal of General Microbiology

Year:

1976

Language:

english

File:

PDF, 754 KB

english, 1976

22

Further debate of testing strategies

Tweats, David J., Gatehouse, David G.

Journal:

Year:

1988

Language:

english

File:

PDF, 665 KB

english, 1988

23

Investigations into the genotoxic potential of loxtidine, a long-acting H 2 -receptor antagonist

Gatehouse, D., Wedd, D.J., Paes, D., Delow, G., Burlinson, B., Pascoe, S., Brice, A., Stemp, G., Tweats, D.J.

Journal:

Year:

1988

Language:

english

File:

PDF, 972 KB

english, 1988

24

Omic profiling for drug safety assessment: current trends and public–private partnerships

William M. Gallagher, David Tweats, Jochen Koenig

Journal:

Drug Discovery Today

Year:

2009

Language:

english

File:

PDF, 644 KB

english, 2009

25

Impact of ICH guidelines on genotoxicity testing

Journal:

Pharmaceutical Science & Technology Today

Year:

1998

Language:

english

File:

PDF, 196 KB

english, 1998

26

Genotoxicity of flubendazole and its metabolites in vitro and the impact of a new formulation on in vivo aneugenicity

Tweats, David J, Johnson, George E, Scandale, Ivan, Whitwell, James, Evans, Dean B

Journal:

Year:

2018

Language:

english

File:

PDF, 900 KB

english, 2018

27

A differential killing assay for mutagens and carcinogens based on an improved repair-deficient strain of Escherichia coli

Tweats, D.J., Green, Michael H.L., Muriel, W.J.

Journal:

Year:

1981

Language:

english

File:

PDF, 1.42 MB

english, 1981

28

Genotoxicity testing—future developments

David J. Tweats

Journal:

Year:

2006

Language:

english

File:

PDF, 69 KB

english, 2006

29

Strategies for screening ‘high-exposure’ chemicals for genotoxicity

D.J. Tweats, D.G. Gatehouse

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1989

Language:

english

File:

PDF, 174 KB

english, 1989

30

Mutation, cancer and transgenic models: relevance to the toxicology industry

Sullivan, Neil, Gatehouse, David, Tweats, David

Journal:

Year:

1993

Language:

english

File:

PDF, 981 KB

english, 1993

31

Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive

Tweats, D.J., Scott, A.D., Westmoreland, C., Carmichael, P.L.

Journal:

Year:

2006

Language:

english

File:

PDF, 117 KB

english, 2006

32

Mitotic gene conversion induced by hycanthone methanesulphonate

D.J. Tweats, D. Gatehouse

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1979

Language:

english

File:

PDF, 63 KB

english, 1979

33

Interaction between the plasmid R6K and Escherichia coli with defective DNA polymerase I

Tweats, D. J., Smith, J. T.

Journal:

Genetics Research

Year:

1978

Language:

english

File:

PDF, 708 KB

english, 1978

34

Studies of error-prone DNA repair in Escherichia coli K-12 and Ames Salmonella typhimurium strains using a model alkylating agent

Little, C.A., Tweats, D.J., Pinney, R.J.

Journal:

Year:

1989

Language:

english

File:

PDF, 485 KB

english, 1989

35

Investigations into the induction of aneuploidy and polyploidy in cultured mammalian cells by the anti-tussive agent, noscapine

D. Gatehouse, G. Stemp, S. Pascoe, P. Wilcox, J. Oliver, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1991

Language:

english

File:

PDF, 78 KB

english, 1991

36

Testing strategies in mutagenicity and genetic toxicology: An appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes

D.J. Kirkland, L. Henderson, D. Marzin, L. Müller, J.M. Parry, G. Speit, D.J. Tweats, G.M. Williams

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2005

Language:

english

File:

PDF, 227 KB

english, 2005

37

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

David Kirkland, Stefan Pfuhler, David Tweats, Marilyn Aardema, Raffaella Corvi, Firouz Darroudi, Azeddine Elhajouji, Hansruedi Glatt, Paul Hastwell, Makoto Hayashi, Peter Kasper, Stephan Kirchner, Ant

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2007

Language:

english

File:

PDF, 2.21 MB

english, 2007

38

Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness

Torreele, Els, Bourdin Trunz, Bernadette, Tweats, David, Kaiser, Marcel, Brun, Reto, Mazué, Guy, Bray, Michael A., Pécoul, Bernard, Boelaert, Marleen

Journal:

PLoS Neglected Tropical Diseases

Year:

2010

Language:

english

File:

PDF, 316 KB

english, 2010

39

Patient, physician, and general population preferences for treatment characteristics in relapsed or refractory chronic lymphocytic leukemia: A conjoint analysis

Landfeldt, Erik, Eriksson, Jennifer, Ireland, Steve, Musingarimi, Patience, Jackson, Claire, Tweats, Emma, Gaudig, Maren

Journal:

Leukemia Research

Year:

2016

Language:

english

File:

PDF, 754 KB

english, 2016

40

Relevance of plasmid pKM101-mediated mutagenicity in bacteria to genotoxicity in mammalian cells

Little, C.A., Tweats, D.J., Pinney, R.J.

Journal:

Year:

1989

Language:

english

File:

PDF, 508 KB

english, 1989

41

Letter to the Editor

Gatehouse, D.G., Tweats, D.J.

Journal:

Year:

1986

Language:

english

File:

PDF, 228 KB

english, 1986

42

Genotoxicity testing: current practices and strategies used by the pharmaceutical industry

Purves, Delphine, Harvey, Christine, Tweats, David, Lumley, Cynthia E.

Journal:

Year:

1995

Language:

english

File:

PDF, 1019 KB

english, 1995

43

Role of aneuploidy in the carcinogenic process: Part III of the Report of the 2017 IWGT workgroup on assessing the risk of aneugens for carcinogenesis and hereditary diseases

Tweats, David, Eastmond, David, Lynch, Anthony M., Elhajouji, Azeddine, Froetschl, Roland, Kirsch-Volders, Micheline, Marchetti, Francesco, Masumura, Kenichi, Pacchierotti, Francesca, Schuler, Maik

Journal:

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Year:

2019

Language:

english

File:

PDF, 436 KB

english, 2019

44

What Relapsed/Refractory Cll/Mcl Treatment Outcomes Do German Patients And Physicians Find Most Important? Results from Qualitative Interviews

Gaudig, M., Ireland, S., Musingarimi, P., Jackson, C., Tweats, E., Eriksson, J.A., Landfeldt, E.

Journal:

Value in Health

Year:

2014

Language:

english

File:

PDF, 66 KB

english, 2014

45

The preclinical toxicological evaluation of sumatriptan

Owen, K., Hartley, K., Tucker, M., Parkinson, M., Tweats, D., Jackson, M.

Journal:

Human & Experimental Toxicology

Year:

1995

Language:

english

File:

PDF, 1.36 MB

english, 1995

46

Does bleeding induce micronuclei via erythropoietin in Han-Wistar rats?

Molloy, Jenny, Foster, John R., Thomas, Helen, O'Donovan, Mike R., Tweats, David, Doherty, Ann T.

Journal:

Toxicology Research

Year:

2014

Language:

english

File:

PDF, 1.23 MB

english, 2014

47

Plasmid pGW16, a derivative of pKM101, increases post-UV DNA synthesis, but sensitises some strains of Escherichia coli to UV

C.A. Little, D.J. Tweats, R.J. Pinney

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

1991

Language:

english

File:

PDF, 760 KB

english, 1991

48

Bacterial mutagenicity tests of β-lactam antibiotics

D.J.V. Paes, D.J. Tweats

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1980

Language:

english

File:

PDF, 66 KB

english, 1980

49

Toxicokinetics and hazard assessment: mutagenicity profile of a prostanoid, GR63799

D.J. Tweats, D.G. Gatehouse, B.A. Duncan, A.J. Brice

Journal:

Mutation Research/Environmental Mutagenesis and Related Subjects

Year:

1992

Language:

english

File:

PDF, 89 KB

english, 1992

50

Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride

Gatehouse, D.G., Stemp, G., Pascoe, S., Wilcox, P., Hawker, J., Tweats, D.J.

Journal:

Year:

1991

Language:

english

File:

PDF, 508 KB

english, 1991

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